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Tear-film breakup: the role of membrane-associated mucin polymers Feng, James J.
Description
with Mohar Dey and Xiaoyang Xu The tear film has a heterogeneous structure. Next to the ocular surface is a region hundreds of nanometers thick that is rich in mucin polymers. Atop this so-called mucus layer lies the aqueous layer, which is up to 5 microns thick. The outer surface of the aqueous layer is covered by a thin lipid layer that is exposed to the ambient air. The mucin protects the ocular epithelium against pathogens, and clinical evidence points to progressive destruction of the membrane-associated mucins (MAM) in eye infection. From a fluid mechanical viewpoint, the MAM modifies the wetting condition on the solid substrate, and modulates the van der Waals forces between the interfaces. We hypothesize that a change in the configuration of the MAM, say from complete coverage to partial coverage, induces a stronger van der Waals attraction and enhances slip on the ocular surface. Both factors should accelerate the breakup of the tear film. This will explain clinical observations of faster tear-film breakup in various eye diseases. We numerically simulate the tear-film breakup process to study the effect of the MAM through an elevated Hamaker constant and a modified slip length. Results show that the loss of MAM indeed precipitates tear-film breakup, and suggest that the tear-film breakup time can be a potential diagnostic of eye diseases.
Item Metadata
Title |
Tear-film breakup: the role of membrane-associated mucin polymers
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Creator | |
Publisher |
Banff International Research Station for Mathematical Innovation and Discovery
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Date Issued |
2019-05-02T09:28
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Description |
with Mohar Dey and Xiaoyang Xu
The tear film has a heterogeneous structure. Next to the ocular surface is a region hundreds of nanometers thick that is rich in mucin polymers. Atop this so-called mucus layer lies the aqueous layer, which is up to 5 microns thick. The outer surface of the aqueous layer is covered by a thin lipid layer that is exposed to the ambient air. The mucin protects the ocular epithelium against pathogens, and clinical evidence points to progressive destruction of the membrane-associated mucins (MAM) in eye infection. From a fluid mechanical viewpoint, the MAM modifies the wetting condition on the solid substrate, and modulates the van der Waals forces between the interfaces.
We hypothesize that a change in the configuration of the MAM, say from complete coverage to partial coverage, induces a stronger van der Waals attraction and enhances slip on the ocular surface. Both factors should accelerate the breakup of the tear film. This will explain clinical observations of faster tear-film breakup in various eye diseases. We numerically simulate the tear-film breakup process to study the effect of the MAM through an elevated Hamaker constant and a modified slip length. Results show that the loss of MAM indeed precipitates tear-film breakup, and suggest that the tear-film breakup time can be a potential diagnostic of eye diseases.
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Extent |
26.0 minutes
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Subject | |
Type | |
File Format |
video/mp4
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Language |
eng
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Notes |
Author affiliation: University of British Columbia
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Series | |
Date Available |
2019-10-30
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0384640
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URI | |
Affiliation | |
Peer Review Status |
Unreviewed
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Scholarly Level |
Faculty
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International