- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- BIRS Workshop Lecture Videos /
- Copy number analysis of circulating cell-free DNA.
Open Collections
BIRS Workshop Lecture Videos
BIRS Workshop Lecture Videos
Copy number analysis of circulating cell-free DNA. Seshan, Venkatraman
Description
Cell-free plasma DNA (cfDNA) is defined as fragments of DNA present in the extracellular fluid. These DNA fragments are mostly derived from cells that underwent apoptosis. In a subject with cancer, cfDNA are derived from both normal and tumor cells and thus it will reflect somatic changes present in the tumor DNA. In this talk we will present a method to estimate tumor fraction from shallow whole genome sequencing and one to estimate allele specific copy numbers from targeted deep sequencing. We will demonstrate the statistical issues and computational challenges faced with data from data from samples that have undergone these assays.
Item Metadata
Title |
Copy number analysis of circulating cell-free DNA.
|
Creator | |
Publisher |
Banff International Research Station for Mathematical Innovation and Discovery
|
Date Issued |
2018-11-05T17:04
|
Description |
Cell-free plasma DNA (cfDNA) is defined as fragments of DNA present
in the extracellular fluid. These DNA fragments are mostly derived from cells
that underwent apoptosis. In a subject with cancer, cfDNA are derived from both
normal and tumor cells and thus it will reflect somatic changes present in the
tumor DNA. In this talk we will present a method to estimate tumor fraction from
shallow whole genome sequencing and one to estimate allele specific copy
numbers from targeted deep sequencing. We will demonstrate the statistical
issues and computational challenges faced with data from data from samples that
have undergone these assays.
|
Extent |
30.0
|
Subject | |
Type | |
File Format |
video/mp4
|
Language |
eng
|
Notes |
Author affiliation: Memorial Sloan Kettering Cancer Center
|
Series | |
Date Available |
2019-05-05
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
|
DOI |
10.14288/1.0378588
|
URI | |
Affiliation | |
Peer Review Status |
Unreviewed
|
Scholarly Level |
Faculty
|
Rights URI | |
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International