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Sensing matrix rigidity: transducing mechanical signals from integrins to the nucleus. Roca-Cusachs, Pere
Description
Cell proliferation and differentiation, as well as key processes in development, tumorigenesis, and wound healing, are strongly determined by the rigidity of the extracellular matrix (ECM). In this talk, I will explain how we combine molecular biology, biophysical measurements, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix rigidity. I will discuss how the properties under force of integrin-ECM bonds, and of the adaptor protein talin, drive and regulate rigidity sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model, which can quantitatively predict the role of integrins, talin, myosin, and ECM receptors, and their effect on cell response. Finally, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus, leading to the activation of the transcriptional regulator YAP.
Item Metadata
| Title |
Sensing matrix rigidity: transducing mechanical signals from integrins to the nucleus.
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| Creator | |
| Publisher |
Banff International Research Station for Mathematical Innovation and Discovery
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| Date Issued |
2016-10-11T10:53
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| Description |
Cell proliferation and differentiation, as well as key processes in development, tumorigenesis, and wound healing, are strongly determined by the rigidity of the extracellular matrix (ECM). In this talk, I will explain how we combine molecular biology, biophysical measurements, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix rigidity. I will discuss how the properties under force of integrin-ECM bonds, and of the adaptor protein talin, drive and regulate rigidity sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model, which can quantitatively predict the role of integrins, talin, myosin, and ECM receptors, and their effect on cell response. Finally, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus, leading to the activation of the transcriptional regulator YAP.
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| Extent |
29.0
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| Subject | |
| Type | |
| File Format |
video/mp4
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| Language |
eng
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| Notes |
Author affiliation: Institute for Bioengineering of Catalonia - Universitat de Barcelona
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| Series | |
| Date Available |
2019-03-05
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0376631
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| URI | |
| Affiliation | |
| Peer Review Status |
Unreviewed
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| Scholarly Level |
Faculty
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International