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BIRS Workshop Lecture Videos

Brain region-specific DNA methylation and chromatin accessibility Hansen, Kasper


Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal and abnormal brain function involve specialized brain regions, yet little is known about brain region-specific epigenetic differences We study DNA methylation and chromatin accessibility in multiple brain regions of the normal human brain using whole-genome bisulfite sequencing and ATAC sequencing. Flow sorting reveals differences between neuronal and glial cells, as well as between brain regions. We show that differences in DNA methylation and accessibility between brain regions are enriched for explained heritability of multiple neurological traits.

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