Title	Brain region-specific DNA methylation and chromatin accessibility
Creator	Hansen, Kasper
Publisher	Banff International Research Station for Mathematical Innovation and Discovery
Date Issued	2017-03-27T15:56
Description	Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal and abnormal brain function involve specialized brain regions, yet little is known about brain region-specific epigenetic differences We study DNA methylation and chromatin accessibility in multiple brain regions of the normal human brain using whole-genome bisulfite sequencing and ATAC sequencing. Flow sorting reveals differences between neuronal and glial cells, as well as between brain regions. We show that differences in DNA methylation and accessibility between brain regions are enriched for explained heritability of multiple neurological traits.
Extent	24 minutes
Subject	Mathematics; Statistics; Biology and other natural sciences
Type	Moving Image
File Format	video/mp4
Language	eng
Notes	Author affiliation: John Hopkins University
Series	BIRS Workshop Lecture Videos (Banff, Alta)
Date Available	2017-09-24
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivatives 4.0 International
DOI	10.14288/1.0355753
URI	http://hdl.handle.net/2429/63099
Affiliation	Non UBC
Peer Review Status	Unreviewed
Scholarly Level	Faculty
Rights URI	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository	DSpace

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