BIRS Workshop Lecture Videos

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BIRS Workshop Lecture Videos

Dynamic models for Lipid Bilayers: from Biosensing to Electroporation Krishnamurthy, Vikram


We discuss and evaluate models for the dynamics of two novel measurement platforms: (i) a Pore Formation Measurement Platform (PFMP) for detecting the presence of pore forming proteins and peptides, (ii) the Ion Channel Switch (ICS) biosensor for detecting the presence of analyte molecules in a fluid chamber. Common to both measurement platforms is that they are comprised of an engineered tethered membrane. The electrical response is modelled using continuum theories for electrodiffusive flow coupled with boundary conditions for modelling chemical reactions and electrical double layers present at the bioelectronic interface. Experimental measurements are used to validate the predictive accuracy of the dynamic models.

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