- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- BIRS Workshop Lecture Videos /
- Beyond clonal interference: scrutinizing the diversity...
Open Collections
BIRS Workshop Lecture Videos
BIRS Workshop Lecture Videos
Beyond clonal interference: scrutinizing the diversity of the stochastic dynamics of three interacting clones Smadi, Charline
Description
In large adapting clonal species, several beneficial mutations can co-occur, affecting the process of adaptation, and especially its rate. Several experimental and theoretical works showed that clonal interference can be an important factor limiting the rate of adaptation. However, models done so far do not embrace the diversity of observed dynamics in experiments, especially non-linear dynamics. We develop here a three-type stochastic birth and death model with explicit competitive interactions between clones and describe the complexity of the emerging dynamics of the population, supposing that two mutants enter a resident population in a single copy at different times. These clones can either get fixed, be lost or be maintained in polymorphism, depending on their competitive abilities. We show that frequency-dependent selection can give rise to unexpected dynamics: competitive interactions between clones can foster adaptation by increasing or decreasing both the fixation probability and time of beneficial mutations.
Item Metadata
Title |
Beyond clonal interference: scrutinizing the diversity of the stochastic dynamics of three interacting clones
|
Creator | |
Publisher |
Banff International Research Station for Mathematical Innovation and Discovery
|
Date Issued |
2016-08-05T11:13
|
Description |
In large adapting clonal species, several beneficial mutations can co-occur, affecting the process of adaptation, and especially its rate. Several experimental and theoretical works showed that clonal interference can be an important factor limiting the rate of adaptation. However, models done so far do not embrace the diversity of observed dynamics in experiments, especially non-linear dynamics. We develop here a three-type stochastic birth and death model with explicit competitive interactions between clones and describe the complexity of the emerging dynamics of the population, supposing that two mutants enter a resident population in a single copy at different times. These clones can either get fixed, be lost or be maintained in polymorphism, depending on their competitive abilities. We show that frequency-dependent selection can give rise to unexpected dynamics: competitive interactions between clones can foster adaptation by increasing or decreasing both the fixation probability and time of beneficial mutations.
|
Extent |
34 minutes
|
Subject | |
Type | |
File Format |
video/mp4
|
Language |
eng
|
Notes |
Author affiliation: IRSTEA
|
Series | |
Date Available |
2017-02-03
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
|
DOI |
10.14288/1.0342340
|
URI | |
Affiliation | |
Peer Review Status |
Unreviewed
|
Scholarly Level |
Other
|
Rights URI | |
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International