BIRS Workshop Lecture Videos

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BIRS Workshop Lecture Videos

Computational principles of synaptic plasticity Fusi, Stefano


Memories are stored, retained, and recollected through complex, coupled processes operating on multiple timescales. To understand the computational principles behind these intricate networks of interactions we construct a broad class of synaptic models that efficiently harnesses biological complexity to preserve numerous memories. The memory capacity scales almost linearly with the number of synapses, which is a substantial improvement over the square root scaling of previous models. This was achieved by combining multiple dynamical processes that initially store memories in fast variables and then progressively transfer them to slower variables. Importantly, the interactions between fast and slow variables are bidirectional. The proposed models are robust to parameter perturbations and can explain several properties of biological memory, including delayed expression of synaptic modifications, metaplasticity, and spacing effects.

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