- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- BIRS Workshop Lecture Videos /
- Reconstructing A/B compartments as revealed by Hi-C...
Open Collections
BIRS Workshop Lecture Videos
BIRS Workshop Lecture Videos
Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data Hansen, Kasper
Description
Analysis of Hi-C data has shown that the genome can be divided into two compartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can be reliably estimated using epigenetic data from several different platforms: the Illumina 450k DNA methylation microarray, DNase hypersensitivity sequencing, single- cell ATAC sequencing and single-cell whole-genome bisulfite sequencing. We do this by exploiting the fact that the structure of long range correlations differs between open and closed compartments. This work makes A/B compartments readily available in a wide variety of cell types, including many human cancers.
Item Metadata
| Title |
Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data
|
| Creator | |
| Publisher |
Banff International Research Station for Mathematical Innovation and Discovery
|
| Date Issued |
2015-08-05T09:50
|
| Description |
Analysis of Hi-C data has shown that the genome can be divided into two compartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can be reliably estimated using epigenetic data from several different platforms: the Illumina 450k DNA methylation microarray, DNase hypersensitivity sequencing, single- cell ATAC sequencing and single-cell whole-genome bisulfite sequencing. We do this by exploiting the fact that the structure of long range correlations differs between open and closed compartments. This work makes A/B compartments readily available in a wide variety of cell types, including many human cancers.
|
| Extent |
37 minutes
|
| Subject | |
| Type | |
| File Format |
video/mp4
|
| Language |
eng
|
| Notes |
Author affiliation: Johns Hopkins University
|
| Series | |
| Date Available |
2016-04-18
|
| Provider |
Vancouver : University of British Columbia Library
|
| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
|
| DOI |
10.14288/1.0300007
|
| URI | |
| Affiliation | |
| Peer Review Status |
Unreviewed
|
| Scholarly Level |
Faculty
|
| Rights URI | |
| Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International