BIRS Workshop Lecture Videos

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BIRS Workshop Lecture Videos

Further Statistical Methods for the Analysis of Ribosome Profiling Data Olshen, Adam


During translation messenger RNA produced by transcription is decoded by ribosomes to produce specific polypeptides. Ribosome profiling, a second generation sequencing technology, was developed to measures the position and counts of ribosomes. When combined with corresponding mRNA sequencing data, ribosome profiling data can give insights into translational efficiency. We developed the Babel framework to discover gene level changes in translational efficiency between different conditions utilizing ribosome profiling data. Here we discuss Babel and also newer statistical approaches to ribosome profiling data.

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