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Title	Models that include supercoiling of topological domains reproduce several known features of interphase chromosomes
Creator	Stasiak, Andrzej
Publisher	Banff International Research Station for Mathematical Innovation and Discovery
Date Issued	2013-11-20
Description	Understanding the structure of interphase chromosomes is essential to elucidate regulatory mechanisms of gene expression. During recent years, high-throughput DNA sequencing expanded the power of chromosome conformation capture (3C) methods that provide information about reciprocal spatial proximity of chromosomal loci. Since 2012 it is known that entire chromatin in interphase chromosomes is organized into regions with strongly increased frequency of internal contacts. These regions, with the average size of about 1Mb were named topological domains. More recent studies demonstrated presence of unconstrained supercoiling in interphase chromosomes. Using Brownian dynamics simulations, we show here that by including supercoiling into models of topological domains one can reproduce and thus provide possible explanations of several experimentally observed characteristics of interphase chromosomes, such as their complex contact maps, for example. Work in collaboration with Fabrizio Benedetti, Julien Dorier, Yannis Burnier.
Extent	30 minutes
Subject	Mathematics Biology and other natural sciences Manifolds and cell complexes Mathematical biology
Type	Moving Image
FileFormat	video/mp4
Language	eng
Notes	Author affiliation: University of Lausanne
Series	BIRS Workshop Lecture Videos (Banff, Alta)
Date Available	2014-08-07
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivs 2.5 Canada
DOI	10.14288/1.0043787
URI	http://hdl.handle.net/2429/49739
Affiliation	Non UBC
Peer Review Status	Unreviewed
Scholarly Level	Faculty
Rights URI	http://creativecommons.org/licenses/by-nc-nd/2.5/ca/
AggregatedSourceRepository	DSpace

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