Title	Models of chromatin spatial organisation in the cell nucleus
Creator	Nicodemi, Mario
Publisher	Banff International Research Station for Mathematical Innovation and Discovery
Date Issued	2013-11-20
Description	In the cell nucleus chromosomes have a complex architecture serving vital functional purposes. Recent experiments have started unveiling the interaction map of DNA sites genome-wide, revealing different levels of organisation at different scales. The principles, though, which orchestrate such a complex 3D structure remain still mysterious. I will give an overview of the picture emerging from classical polymer physics of some general aspect of chromatin spatial organisation. The available experimental data, which can be rationalised in a single framework, support a picture where chromatin is a complex mixture of differently folded regions, self-organised across spatial scales according to basic physical mechanisms. I will also discuss applications to specific DNA loci, where models informed with biological details are tested against targeted experiments. Work in collaboration with M. Barbieri, M. Chotalia, L.M. Lavitas, J. Fraser, J. Dostie, A. Pombo.
Extent	29 minutes
Subject	Mathematics; Biology and other natural sciences; Manifolds and cell complexes; Mathematical biology
Type	Moving Image
File Format	video/mp4
Language	eng
Notes	Author affiliation: Universita' di Napoli
Series	BIRS Workshop Lecture Videos (Banff, Alta)
Date Available	2014-08-07
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivs 2.5 Canada
DOI	10.14288/1.0043786
URI	http://hdl.handle.net/2429/49738
Affiliation	Non UBC
Peer Review Status	Unreviewed
Scholarly Level	Faculty
Rights URI	http://creativecommons.org/licenses/by-nc-nd/2.5/ca/
Aggregated Source Repository	DSpace

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Models of chromatin spatial organisation in the cell nucleus Nicodemi, Mario

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