Title	Lattice knots and links in tubes
Creator	Shimokawa, Koya
Publisher	Banff International Research Station for Mathematical Innovation and Discovery
Date Issued	2013-11-18
Description	In Escherichia coli, complete unlinking of newly replicated sister chromosomes is required to ensure their proper segregation at cell division. While replication links are removed primarily by topoisomerase IV (TopoIV), XerCD-dif site-specific recombination can mediate sister chromosome unlinking in TopoIV-deficient cells. This reaction is activated at the division septum by the DNA translocase FtsK, which coordinates the last stages of chromosome segregation with cell division. It has been proposed that, after being activated by FtsK, XerCD-dif recombination removes DNA links in a stepwise manner. Here we provide a mathematically rigorous characterization of this topological mechanism of DNA unlinking. We show that stepwise unlinking is the only possible pathway that strictly reduces the complexity of the substrates at each step. Finally, we propose a topological mechanism for this unlinking reaction. This is a joint work with: Kai Ishihara, Ian Grainge, David J. Sherratt, and Mariel V azquez.
Extent	30 minutes
Subject	Mathematics; Biology and other natural sciences; Manifolds and cell complexes; Mathematical biology
Type	Moving Image
File Format	video/mp4
Language	eng
Notes	Author affiliation: Saitama University
Series	BIRS Workshop Lecture Videos (Banff, Alta)
Date Available	2014-08-07
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivs 2.5 Canada
DOI	10.14288/1.0043777
URI	http://hdl.handle.net/2429/49728
Affiliation	Non UBC
Peer Review Status	Unreviewed
Scholarly Level	Faculty
Rights URI	http://creativecommons.org/licenses/by-nc-nd/2.5/ca/
Aggregated Source Repository	DSpace

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Lattice knots and links in tubes Shimokawa, Koya

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