UBC Graduate Research

Scared to be scarred? Prevent gut fibrosis with bile acids Kabil, Ahmed

Description

Ahmed Kabil was a finalist in the 2024 UBC Three Minute Thesis (3MT) competition. Ahmed presented their research, "Scared to be scarred? Prevent gut fibrosis with bile acids." They hope to not only shed light on the complex relationship between our immune system and gut bacteria but also open the door to innovative therapies for managing and preventing fibrosis, potentially saving countless lives. Fibrosis, an excessive buildup of scar tissue, poses a critical challenge in medicine, often leading to organ failure and death if unchecked. Ahmed’s groundbreaking research uncovers a previously unknown cause: a newly identified group of immune cells in the gastrointestinal tract that behave irregularly (rebel), contributing to this dangerous overgrowth of scar tissue. Intriguingly, we discovered that a certain molecule, a secondary bile acid produced by gut bacteria (microbiome), holds the key to keeping these immune cells educated. This molecule has the unique ability to temper and reduce fibrosis in the gut, offering a promising new avenue for treatment. Ahmed Kabil is completing their PhD in Biomedical Engineering in the School of Biomedical Engineering under the supervision of Dr. Kelly McNagny.

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Attribution-NonCommercial-NoDerivatives 4.0 International